實驗方案：

1. 小鼠適應性生長后隨機分組；

2. 地塞米松作為陽性對照藥， LPS滴鼻刺激前半小時和后6小時給藥；

3. LPS刺激24小時后處死小鼠，收集肺泡灌洗液和肺；

4. 檢測灌洗液細胞因子以及細胞侵潤情況；

5. 肺做病理檢測；

Brief protocol of LPS induced lung injury

1. After one week acclimation, mice will be randomly divided into several groups;

2. DEX will be used as ref cpd. 3 mpk DEX will be administrated 0.5h prior LPS challenge and 6h post LPS challenge;

3. 24h post LPS challenge, mice will be sacrificed, followed by BAL fluid and lung tissue collection;

4. cytokine and cell infiltration in BALF will be measured accordingly;

5. Lung will be used as Histopathology analysis.