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CCL14a, also known as HCC-1 （Hematopoietic Cell-Derived CC Chemokine 1）, is a chemokine belonging to the CC chemokine family. It is involved in immune regulation and inflammation. CCL14a/HCC-1 is produced by various cell types, including monocytes, macrophages, and dendritic cells, in response to inflammatory stimuli.
CCL14a/HCC-1 functions by binding to specific chemokine receptors on target cells, such as CCR1 and CCR5, to induce chemotaxis and activation of immune cells. It plays a role in recruiting leukocytes to sites of inflammation and modulating immune responses.
Research has shown that CCL14a/HCC-1 is implicated in various physiological and pathological processes, including immune cell trafficking, inflammatory diseases, and cancer. Understanding the role of CCL14a/HCC-1 in these processes may provide insights into potential therapeutic strategies for targeting this chemokine in the treatment of related conditions.