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Fibroblast growth factor （FGF-7）, a member of FGF family, is initially found to be secreted from mesenchymal cells to repair epithelial tissues. As a well-characterized paracrine growth factor for tissue growth and regeneration, fibroblast growth factor 7 （FGF-7） is involved in a number of physiological and pathological processes, including lung disease and cancer. The stromal-derived FGFs, such as FGF-7 and FGF-10, control epithelial cell resident FGFR2IIIb activities, promote net tissue homeostasis, and restraint tumor cells from progression to malignancy.