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目錄:杭州斯達(dá)特生物科技有限公司>>抗體/抗原>>功能性抗體>> S0B1142NA/LE Syrian Hamster anti-Mouse CD28 Recombinant mAb

NA/LE Syrian Hamster anti-Mouse CD28 Recombinant mAb
  • NA/LE Syrian Hamster anti-Mouse CD28 Recombinant mAb
參考價(jià) 1200
具體成交價(jià)以合同協(xié)議為準(zhǔn)
參考價(jià) 1200
具體成交價(jià)以合同協(xié)議為準(zhǔn)
  • 品牌 Starter/斯達(dá)特
  • 型號 S0B1142
  • 廠商性質(zhì) 生產(chǎn)商
  • 所在地 杭州市
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更新時(shí)間:2025-07-14 20:46:57瀏覽次數(shù):65評價(jià)

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NA/LE Syrian Hamster anti-Mouse CD28 Recombinant mAb

CD28 is a critical costimulatory receptor expressed on the surface of T cells, particularly on CD4+ and CD8+ T cells, and plays a pivotal role in T cell activation, proliferation, and survival. It is a homodimer of 44kDa subunits, each containing a single immunoglobulin-like extracellular domain, and is part of the Ig superfamily. CD28 interacts with its ligands, CD80 (B7-1) and CD86 (B7-2), which are predominantly found on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. The engagement of CD28 with these ligands is essential for providing the second signal required for full T cell activation, which complements the antigen-specific signal delivered by the T cell receptor (TCR). CD28 signaling leads to the upregulation of IL-2 and its receptor expression, enhances T cell proliferation, and promotes the production of various cytokines, including IL-4, IL-5, IL-13, IFN-γ, and TNF. It also plays a role in the differentiation of T cells into memory phenotypes and in maintaining immune homeostasis. The absence of CD28 signaling results in reduced T cell survival and impaired antibody responses to T-dependent antigens. CD28 is thus a key regulatory point for successful B cell, macrophage, and cytotoxic T cell responses.

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