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CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells.CD16 has been identified as Fc receptors FcγRIIIa （CD16a） and FcγRIIIb （CD16b）, which participate in signal transduction.The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily （IgSF） involved in antibody-dependent cellular cytotoxicity （ADCC）.It can be used to isolate populations of specific immune cells through fluorescent-activated cell sorting （FACS） or magnetic-activated cell sorting, using antibodies directed towards CD16.