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Vimentin is a type III intermediate filament （IF） protein that is expressed in mesenchymal cells. IF proteins are found in all animal cells as well as bacteria. Intermediate filaments, along with tubulin-based microtubules and actin-based microfilaments, comprises the cytoskeleton. All IF proteins are expressed in a highly developmentally-regulated fashion; vimentin is the major cytoskeletal component of mesenchymal cells. Because of this, vimentin is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-to-mesenchymal transition （EMT） during both normal development and metastatic progression. It can be used as a differential diagnosis between epithelial tumors and mesenchymal tumors, as well as for endometrial adenocarcinoma and cervical adenocarcinoma.