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The molecular weights of CK5/6 （Cytokeratin 5/6） are 56kDa and 58kDa. Expressed in basal and stratum spinosum of the skin, as well as in the prostate basal cells and squamous epithelial cells. It can be used for the differential diagnosis of squamous cell carcinoma and adenocarcinoma, as well as mesothelioma and adenocarcinoma. It combined with p63 and AMACR/p504s for diagnosis of benign and malignant prostatic lesions.