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Mammaglobin-A is a novel breast cancer-associated antigen that was initially identified using a differential screening approach. Subsequently, it has been demonstrated that MGBA has several unique properties which make it a promising target for immune therapy. Gene expression analysis of over 20 different human tissues demonstrated that MGBA is expressed almost exclusively in normal breast epithelium and breast cancer. MGBA is over expressed in up to 80% of primary and metastatic breast cancers.