亚洲精品综合日韩中文字幕网站_精品综合久久久久97_中文在线天堂网www_久久精品免费一区二区三区_91久久国产综合精品女同国语_久久资源总站在线国产成人

CD4 is a glycoprotein expressed on the surface of certain immune cells, most notably helper T cells. It is a member of the immunoglobulin superfamily and has four immunoglobulin-like domains （D1 to D4）. CD4 acts as a co-receptor with the T-cell receptor （TCR） to recognize antigens displayed by MHC class II molecules on antigen-presenting cells. The D1 domain of CD4 binds to the β2 region of MHC class II, bringing the TCR complex and CD4 into close proximity. This allows the tyrosine kinase Lck, bound to the cytoplasmic tail of CD4, to phosphorylate tyrosine residues on the cytoplasmic domains of CD3, amplifying the signal generated by the TCR. CD4 is also the primary receptor for the human immunodeficiency virus （HIV）, and its interaction with the HIV gp120 protein is a key step in viral entry.