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目錄:杭州斯達(dá)特生物科技有限公司>>抗體/抗原>>流式抗體>> S0B5072Mouse Anti-Human CD154 Antibody (S-R579)

Mouse Anti-Human CD154 Antibody (S-R579)
  • Mouse Anti-Human CD154 Antibody (S-R579)
參考價(jià) 600
具體成交價(jià)以合同協(xié)議為準(zhǔn)
參考價(jià) 600
具體成交價(jià)以合同協(xié)議為準(zhǔn)
  • 品牌 Starter/斯達(dá)特
  • 型號(hào) S0B5072
  • 廠商性質(zhì) 生產(chǎn)商
  • 所在地 杭州市
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更新時(shí)間:2025-07-12 12:32:50瀏覽次數(shù):28評(píng)價(jià)

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Mouse Anti-Human CD154 Antibody (S-R579)

CD154, also known as CD40 ligand (CD40L), is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily. It is predominantly expressed on activated CD4+ T cells, but can also be found on other immune cells such as monocytes, natural killer cells, and platelets. CD154 interacts with CD40, a receptor expressed on antigen-presenting cells (APCs), B cells, and other immune cells, and is crucial for T cell activation, B cell proliferation and differentiation, and the production of various cytokines. This interaction is essential for the adaptive immune response, including B cell class switching, germinal center formation, and the generation of memory B cells. Mutations in the CD154 gene can lead to X-linked hyper-IgM syndrome, an immunodeficiency characterized by a lack of IgG, IgA, and IgE antibodies. Additionally, CD154 is involved in various inflammatory processes and has been implicated in conditions such as atherosclerosis.

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