亚洲精品综合日韩中文字幕网站_精品综合久久久久97_中文在线天堂网www_久久精品免费一区二区三区_91久久国产综合精品女同国语_久久资源总站在线国产成人

CD45.1 is a protein isoform of CD45, also known as PTPRC, which is a receptor-type tyrosine phosphatase expressed on all hematopoietic cells except erythrocytes and platelets. This type I transmembrane protein plays a crucial role in the activation processes of B and T cell receptors, as well as in thymic selection. CD45.1, along with CD45.2, is commonly used in adoptive cell transfer experiments to distinguish donor cells from host cells due to their allelic differences. Mice carrying the CD45.1 allele, such as C57BL/6J, are widely used in research for this purpose. CD45.1 is also used in studies to understand the rejuvenating effects of young blood on aged tissues. In heterochronic parabiosis models, where the circulatory systems of old and young mice are connected, CD45.1 and CD45.2 genotypes are used to track the cells of old and young mice, respectively.