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目錄:杭州斯達(dá)特生物科技有限公司>>抗體/抗原>>流式抗體>> S0B1636Alexa Fluor? 488 Mouse Anti-Human CD3 Antibody (S-R476)

Alexa Fluor? 488 Mouse Anti-Human CD3 Antibody (S-R476)
  • Alexa Fluor? 488 Mouse Anti-Human CD3 Antibody (S-R476)
參考價 650
具體成交價以合同協(xié)議為準(zhǔn)
參考價 650
具體成交價以合同協(xié)議為準(zhǔn)
  • 品牌 Starter/斯達(dá)特
  • 型號 S0B1636
  • 廠商性質(zhì) 生產(chǎn)商
  • 所在地 杭州市
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更新時間:2025-07-11 19:44:25瀏覽次數(shù):36評價

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Alexa Fluor? 488 Mouse Anti-Human CD3 Antibody (S-R476)

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex. The CD3–T cell receptor (TCR) complex plays a central role in the T-cell-mediated immunoresponse as it is involved in the recognition of antigens and subsequent signal transduction and activation of immunocompetent T lymphocytes. Because CD3 is required for T cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies (e.g., otelixizumab, teplizumab) for type 1 diabetes and other autoimmune diseases.

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