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Vascular endothelial growth factor C （VEGF-C） is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor （PDGF/VEGF） family. The main function of VEGF-C is to promote the growth of lymphatic vessels （lymphangiogenesis）. It acts on lymphatic endothelial cells （LECs） primarily via its receptor VEGFR-3 promoting survival, growth and migration. In human tumour tissue samples VEGF-C was detected in some carcinomas in the low protein range. The ELISA will be a useful tool for investigations concerning the physiological function of VEGF-C in lymphangiogenesis under normal and pathophysiological conditions.