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肝星狀細(xì)胞（Hepatic Stellate Cells) 是各種致纖維化因素的最終靶細(xì)胞，正常情況下肝星狀細(xì)胞處于靜止?fàn)顟B(tài)，當(dāng)肝臟受到炎癥或機(jī)械刺激等損傷時(shí)，肝星狀細(xì)胞被激活，其表型由靜止型轉(zhuǎn)變?yōu)榧せ钚汀?span>


應(yīng)用方向

1）HSC與肝纖維化
2）HSC與肝臟發(fā)育和再生
3）HSC與肝腫瘤
4）HSC與免疫系統(tǒng)

用戶反饋

（上圖為藥企研發(fā)部門提供）

2016-2019 論文引用（部分）

1. Deng M, Xu L, Xie X et al., .Downregulation of syndecan?1 expression induces activation of hepatic stellate cells via the TGF?β1Smad3 signaling pathway. Mol Med Rep. 2019; 20(1):368-74.
3. Zhang F, Lu S, He J et al., Ligａnd activation of PPARγ by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1α. Theranostics 2018; 8(3): 610-26.
5. Zhang F, Jin H, Wu L et al., Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells through production of hydrogen sulfide. Oxid Med Cell Longev. 2017; 2017:1406726.
7. Lian N, Jin H, Zhang F et al., Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate‐activated protein kinase. IUBMB Life. 2016; 68(7):589-96.
9. He L, Hou X, Fan F et al., Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells. Pharm Biol. 2016,; 54(12):3237-43.
11. Zhang F, Lu C, Xu W et al., Curcumin raises lipid content by Wnt pathway in hepatic stellate cell. J Surg Res. 2016; 200(2): 460-6.

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