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上海允麥生物科技有限公司
中級(jí)會(huì)員·7年
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- 麥經(jīng)理
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Recombinant human ZAP70
ZAP-70; ZAP 70; zeta-associated protein 70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; Syk-related tyrosine kinase. SRK; STD; TZK; ZAP70_HUMAN; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein.
濃度：1mg/ ml
來(lái)源：Recombinant Human
純度：≥90% SDS-PAGE
表達(dá)系統(tǒng)：Baculovirus infected Sf9 cells
標(biāo)簽：GST tag N-Terminus
蛋白長(zhǎng)度：Full length protein
內(nèi)毒素水平：<1.000 Eu/µg
純化方法：HPLC
應(yīng)用：SDS-PAGE，Western blot，ELISA
Biological activity,immunology research
保存：-20℃
保質(zhì)期：1年
Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.Expressed in T- and natural killer cells.Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.The SH2 domains bind to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z and the non-canonical phosphorylated tyrosine-based activation motif (TAM) of RHOH.
多克隆抗體：
產(chǎn)品名稱：Rabbit Anti-ZAP70 antibody
Rabbit Anti-ZAP70
別名：ZAP-70; ZAP 70; zeta-associated protein 70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; Syk-related tyrosine kinase. SRK; STD; TZK; ZAP70_HUMAN; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein.
來(lái)源：Rabbit
克隆類型：Polyclonal
濃度：1mg/ml
亞型：IgG
反應(yīng)：Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Chicken,Dog,GuineaPig,Horse)
應(yīng)用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
理論分子量：68kDa
免疫原：KLH conjugated synthetic peptide derived from human ZAP70
保存：-20℃
保質(zhì)期：1年
單克隆抗體
產(chǎn)品名稱：Anti-ZAP70 antibody
Mouse Anti-ZAP70
別名：ZAP-70; ZAP 70; zeta-associated protein 70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; Syk-related tyrosine kinase. SRK; STD; TZK; ZAP70_HUMAN; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein.
來(lái)源：Mouse
克隆類型：Monoclonal
濃度：1mg/ml
亞型：IgG
反應(yīng)：Human
應(yīng)用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
反應(yīng): Human
理論分子量：68kDa
免疫原：KLH conjugated synthetic peptide derived from human ZAP70
保存：-20℃
保質(zhì)期：1年
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
