Thermo A36742 POROS CaptureSelect

Thermo A36742 POROS CaptureSelect

Thermo Scientific™

POROS™ CaptureSelect™ AAVX Affinity Resin

货号: A36742

POROS CaptureSelect AAVX Affinity Resin is engineered to address the high selectivity and capacity requirements for large-scale downstream purification of a broad range of naturally occurring and synthetic adeno-associated virus (AAV) serotypes used for gene therapy applications. POROS CaptureSelect AAVX resin has demonstrated binding reactivity towards a set of AAV serotypes that includes AAV1 to AAV8, and AAVrh10 as well as synthetic serotypes.

Thermo A36742 POROS™ CaptureSelect™ AAVX Affinity Resin

Features of POROS CaptureSelect AAVX resin include:

• One-step AAV purification from crude material with high purity and yield

• High specificity and capacity, maximizing yield by significantly reducing process steps

• Superior capacity maintained at high flow rates

• Excellent scalability and easier handling and packing due to rigid polymeric bead

• Non-animal derived

POROS CaptureSelect AAVX Affinity Resin enables a robust, fast, and platformable purification process for wide-ranging AAV serotypes with excellent purity and yield obtained in one step. This resin comes with complete technical and regulatory support.

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Main characteristics

Matrix: cross-linked poly(styrene-divinylbenzene) POROS beads

Average particle size: 50 µm

Ligand: CaptureSelect AAVX affinity ligand

Binding capacity: >1x1013 genome copies/mL of resin

Elution conditions: acidic elution with 0.1 M glycine, pH 3.0

Mechanical resistance: 100 bar (1,450 psi; 10 MPa)

Formulation buffer: 18% (v/v) ethanol

Free of animal components

CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a 12 to 15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).

货号 单位规格

A36742 250 mL

A36739 10 mL

A36740 25 mL

A36741 50 mL

A36743 1,000 mL

A36744 5,000 mL

A36745 10,000 mL

规格

配基类型:CaptureSelect AAVX affinity ligand

粒径:50 μm

数量:250 mL

产品线:POROS™

结合功能:>1x1013 genome copies/mL of resin

运输条件:Wet Ice

基质:Cross-linked poly(styrene-divinylbenzene) POROS beads

色谱柱类型:Affinity