Cytokeratin 17(细胞角蛋白17)

广州健仑生物科技有限公司

细胞角蛋白17 分子量为46kDa，表达于复层上皮和气管、喉、支气管假复层柱状上皮的基底细胞以及唾液腺的肌上皮细胞。在肿瘤组织中，该抗体主要识别肺、子宫颈和口腔的鳞状细胞癌。主要用于鳞状细胞癌的研究。

诊断应用：
1． 癌的鉴别
2． 显示不同上皮样分化肉瘤的鉴别
1. 滑膜肉瘤
2. 上皮样肉瘤
3． 肉瘤中的异常染色可为间皮瘤、黑色素瘤、平滑肌肉瘤和内皮细胞肿瘤的诊断提供线索，通常只有CK8和CK18（被Cam5.2和35BH11证明）表达阳性，这两种存在于所有组织中的原始角蛋白胚胎源性表达也许可以解释CK8和CK18的异位性表达。
4． 在小细胞癌中可以看到细胞核周“圆点状”染色，如美克尔细胞癌、肉瘤及髓细胞瘤可显示异常免疫反应性。
5． 许多“儿童的小蓝圆细胞肿瘤”表达角蛋白，包括尤文氏肉瘤/PNET、横纹肌肉瘤、肾母细胞瘤和促结缔组织增生性小圆细胞肿瘤。
细胞角蛋白Moll数
除了表格所列的20种软角蛋白外，还有限于头发、指甲上皮组织的硬角蛋白。细胞角蛋白zui初的分类建立在2D凝胶电泳的基础上。现在有特异的单克隆抗体可应用于石蜡包埋的组织，由于细胞角蛋白之间的同源性，单抗需十分仔细地筛选以避免交叉反应?？乖龆ù卦谀承┣榭鱿驴梢员徽诒?，可能反应发生在免疫印迹上而不是在组织切片。

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Cytokeratin 17(细胞角蛋白17)

【产品介绍】

细胞定位：细胞浆

克隆号：Ks17.E3

同型：IgG2b

适用组织：石蜡/冰冻

阳性对照：乳腺/宫颈

抗原修复：热修复（EDTA）

抗体孵育时间：30-60min

Cytokeratin 17(细胞角蛋白17)

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【公司名称】 广州健仑生物科技有限公司
【市场部】     欧

【】 
【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

Cytokeratin 17 has a molecular weight of 46 kDa and is expressed on the epithelium of the stratified epithelium and in the trachea, larynx, bronchial pseudostratified columnar epithelium, and myoepithelial cells of the salivary gland. In tumor tissue, the antibody mainly recognizes squamous cell carcinomas of the lung, cervix and mouth. Mainly used for squamous cell carcinoma research.

Diagnostic Applications:
1. Cancer identification
2. Identification of different epithelioid differentiated sarcomas
Synovial sarcoma
2. Epithelioid sarcoma
3. Abnormal staining in sarcomas can provide clues to the diagnosis of mesothelioma, melanoma, leiomyosarcoma and endothelial cell tumors, which are usually only positive for CK8 and CK18 (evidenced by Cam5.2 and 35BH11), both present in all tissues The original keratin-derived expression may explain the ectopic expression of CK8 and CK18.
4. Small cell carcinoma can be seen in the perinuclear "dot-like" staining, such as melanocarcinoma, sarcoma and myeloblastoma can show abnormal immunoreactivity.
5. Many "small blue circle cell tumors in children" express keratin, including Ewing's Sarcoma / PNET, rhabdomyosarcoma, Wilms' tumor, and connective tissue proliferating small round cell tumors.
Cytokeratin Moll number
In addition to the 20 types of soft keratins listed in the table, there is limited to keratin hair and nail epithelium. The initial classification of cytokeratin was based on 2D gel electrophoresis. Specific monoclonal antibodies are now available for use in paraffin-embedded tissues. Due to the homology between cytokeratins, the monoclonal antibodies should be carefully screened to avoid cross-reactivity. Epitopes can be obscured in some cases, and the reaction may occur on immunoblots rather than on tissue sections.