亚洲精品综合日韩中文字幕网站_精品综合久久久久97_中文在线天堂网www_久久精品免费一区二区三区_91久久国产综合精品女同国语_久久资源总站在线国产成人

深圳欣博盛生物科技有限公司
中級(jí)會(huì)員 | 第5年

13129540117

當(dāng)前位置:深圳欣博盛生物科技有限公司>>天然免疫研究產(chǎn)品>> LPS-PG (Standard)

LPS-PG (Standard)

參   考   價(jià): 2670

訂  貨  量: ≥1  件

具體成交價(jià)以合同協(xié)議為準(zhǔn)

產(chǎn)品型號(hào)

品       牌Invivogen

廠商性質(zhì)代理商

所  在  地深圳市

更新時(shí)間:2022-01-29 09:50:52瀏覽次數(shù):1084次

聯(lián)系我時(shí),請(qǐng)告知來(lái)自 化工儀器網(wǎng)
同類(lèi)優(yōu)質(zhì)產(chǎn)品更多>
供貨周期 現(xiàn)貨 規(guī)格 1 mg
貨號(hào) tlrl-pglps 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)
主要用途 科研
LPS-PG is a purified preparation of lipopolysaccharide (LPS) from the Gram-negative bacteria Porphyromonas gingivalis. LPS-PG is an important virulence factor in the mechanisms of peridontal disease.…

Lipopolysaccharide from Porphyromonas gingivalis

LPS-PG is a purified preparation of lipopolysaccharide (LPS) from the Gram-negative bacteria Porphyromonas gingivalis. LPS-PG is an important virulence factor in the mechanisms of peridontal disease. LPS is the principal component of Gram negative bacteria that activates the innate immune system.

LPS recognition is predominantly mediated by TLR4 [1]. The TLR4 response to LPS-PG is dependent on the presence of key accessory molecules, CD14 and MD2 [2].

LPS-PG presents a unique and heterogenous chemical structure, which differs from traditionally recognized enteric bacterium-derived LPS. The fact that LPS-PG exhibits activity in C3H/HeJ mice, which are deficient for TLR4, led to a common belief that this LPS is a TLR2 ligand [3, 4].

However, structural and functional studies of LPS-PG have revealed that it activates cells through TLR4.

The TLR2 activity of LPS-PG is ascribed to a contaminant lipoprotein [5].

InvivoGen provides LPS-PG with two grades of purity:

  • LPS-PG is a standard lipopolysaccharide (LPS) preparation.

  • LPS-PG Ultrapure underwent enzymatic treatment to remove lipoproteins and hence only activates TLR4.

 

References:

1. Poltorak A. et al., 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene. Science, 282:2085-8.
2. Darveau RP. et al., 2004. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun. 72(9):5041-51.
3. Kirikae T. et al., 1999. Lipopolysaccharides (LPS) of oral black-pigmented bacteria induce tumor necrosis factor production by LPS-refractory C3H/HeJ macrophages in a way different from that of Salmonella LPS. Infect Immun. 67(4):1736-42.
4. Hirschfeld M. et al., 2001. Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun. 69(3):1477-82.
5. Ogawa T. et al., 2007. Chemical structure and immunobiological activity of Porphyromonas gingivalis lipid A. Front Biosci. 12:3795-812.


Specifications

Specificity:

  • LPS-PG (Standard): TLR2/TLR4 agonist

  • LPS-PG Ultrapure: TLR4 agonist

Working concentrations :

LPS-PG (Standard):

  • TLR4 activity: 100 ng - 10 μg/ml

  • TLR2 activity: 10 ng/ml - 10 mg/ml

LPS-PG Ultrapure:

  • TLR4 activity: 100 ng- 10 μg/ml

Quality control :

  • The TLR4 activity is controlled using HEK-Blue™ TLR4 cells.

  • The presence of other bacterial components (e.g. lipoproteins) is controlled using HEK-Blue™ TLR2 cells.


Contents

LPS-PG is provided lyophilized :

LPS-PG (Standard):

  • 1 mg of a preparation of lipopolysaccharide from Porphyromonas gingivalis (LPS-PG Standard)

  • 1.5 ml endotoxin-free water

LPS-PG Ultrapure:

  • 1 mg of an ultra pure preparation of lipopolysaccharide from Porphyromonas gingivalis (LPS-PG Ultrapure)

  • 1.5 ml endotoxin-free water

 LPS-PG is shipped at room temperature.

 Store at -20°C.

Upon resuspension, prepare aliquots of LPS-PG and store at 4°C for short term storage or -20°C for long storage.

Resuspended product is stable 1 month at 4°C and 6 months at -20°C when properly stored.


如需購(gòu)買(mǎi)或咨詢(xún)?cè)摦a(chǎn)品技術(shù)問(wèn)題,請(qǐng)聯(lián)系Invivogen一級(jí)代理商--欣博盛生物

會(huì)員登錄

×

請(qǐng)輸入賬號(hào)

請(qǐng)輸入密碼

=

請(qǐng)輸驗(yàn)證碼

收藏該商鋪

X
該信息已收藏!
標(biāo)簽:
保存成功

(空格分隔,最多3個(gè),單個(gè)標(biāo)簽最多10個(gè)字符)

常用:

提示

X
您的留言已提交成功!我們將在第一時(shí)間回復(fù)您~
撥打電話
在線留言
建德市| 灵丘县| 繁峙县| 怀化市| 梨树县| 乌兰浩特市| 乌拉特后旗| 南充市| 如东县| 留坝县| 那曲县| 龙口市| 商河县| 新田县| 黄浦区| 阿克| 衡阳县| 青冈县| 永定县| 遂川县| 威宁| 武鸣县| 丹阳市| 天水市| 浏阳市| 陈巴尔虎旗| 佳木斯市| 江阴市| 舞钢市| 建瓯市| 上虞市| 太保市| 遂昌县| 个旧市| 东方市| 林周县| 昭觉县| 郯城县| 历史| 长春市| 巴中市|