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上海橋星貿(mào)易有限公司
主營產(chǎn)品： 進口透析袋,密理博ECL發(fā)光液,B27無血清培養(yǎng)基,Gibco膠原酶 |
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上海橋星貿(mào)易有限公司
主營產(chǎn)品： 進口透析袋,密理博ECL發(fā)光液,B27無血清培養(yǎng)基,Gibco膠原酶 |
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2019-8-12 閱讀(1800)
5-氮雜-2′-脫氧胞苷
5-氮雜-2′-脫氧胞苷
性質
Related Categories AN-AZ, Approved Therapeutics/Drug Candidates,Bioactive Small Molecule Alphabetical Index, Eisai,Fluorination Ready Pharma-Developed Compounds,
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InChI Key XAUDJQYHKZQPEU-KVQBGUIXSA-N
assay ≥97%
solubility acetic acid: water (1:1): 50 mg/mL
originator Eisai
產(chǎn)品描述
包裝
5, 10 mg in glass bottle
50 mg in glass insert
Application
5-Aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, DNA and promoter region of p16 gene.[3][4][5][6]
Biochem/physiol Actions
5′-脫氧雜氮胞苷可引起DNA去甲基化或半去甲基化。DNA去甲基化可通過隨著提高的核酸酶活性而“打開”染色質的結構來調控基因的表達。這種染色質結構的重塑可實現(xiàn)轉錄因子與啟動子區(qū)域的結合、轉錄復合物的組裝及基因表達。
Features and Benefits
該化合物是基因調控研究的特色產(chǎn)品。點擊此處以了解更多的基因調控特色產(chǎn)品。
General description
5-Aza-2′-deoxycytidine is a DNA-hypomethylating agent, which stimulates differentiation and apoptosis of leukemic cells.[1] It is a 2′-deoxycytidine analogue.[2] 5-Aza-2′-deoxycytidine is used to treat chronic myelomonocytic leukemia, refractory anemia, myelodysplastic syndrome and acute myeloid leukemia.
