µ-conotoxin GIIIB（µ-芋螺毒素 GIIIB）

Selective blocker of Na_v1.4 channels(钠离子通道Na_v1.4选择性阻断剂)

µ-conotoxin GIIIB is a 22-mer peptide originally isolated from the venom of the piscivorous marine snail Conus geographus. µ-conotoxin GIIIB adopts a compact structure consisting of a distorted 3₁₀-helix and a small ß-hairpin. µ-conotoxin GIIIB is stabilized by three disulphide bridges and is highly enriched in lysine and arginine residues, forming potential sites of interaction with Na channels. An unusual feature is the presence of three hydroxyproline residues. µ-conotoxin GIIIB is a useful probe to discriminate between neuronal and muscle sodium channels as it exhibits at least a 1000-fold specificity for muscle versus nerve sodium channels. µ-Conotoxin GIIIB selectively blocks Na_v1.4(µ1) voltage-dependent sodium channels, which are predominantly expressed in muscle, with an affinity close to 20 nM.µ-Conotoxin GIIIB appears to physically occlude the channel pore by binding on site I of the Na⁺ channel. 

µ-conotoxin GIIIB 技术资料

氨基酸序列：

Arg-Asp-Cys³-Cys⁴-Thr-Hyp-Hyp-Arg-Lys-Cys¹⁰-Lys-Asp-Arg-Arg-Cys¹⁵-Lys-Hyp-Met-Lys-Cys²⁰-Cys²¹-Ala-NH₂ 

二硫键： Cys³-Cys¹⁵, Cys⁴-Cys²⁰ and Cys¹⁰-Cys²¹ 

长度 (aa)： 22 

分子式： C₁₀₁H₁₇₅N₃₉O₃₀S₇ 

分子量：2640.26 Da 

外观：White lyophilized solid 

可溶性：water and saline buffer 

CAS 号：not available 

来源： Synthetic  

纯度：> 97 %

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