CBP10144 | |
| Format | Genomic DNA |
| Description | TP53 Y220C is a hotspot mutation that lies within the DNA-binding domain (PMID: 17401432). Y220C is predicted to confer a loss of function to the Tp53 protein, as demonstrated by decreased Tp53 transcriptional activity in cell culture (PMID: 16861262, PMID: 23630318). |
| Technical Data | |
| DNA Change: | c.659A>G |
| AA Change | p.Y220C |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM10758 |
| Chr position(GRCh37) | chr17:7578190 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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