| CBP74038 | |
| I. Background | |
| OX40 (CD134) is a co-stimulatory receptor expressed on the surface of CD4+ and CD8+ T cells 24 to 48 hours after activation. Binding of OX40 to its ligand, OX40L (CD252), present on dendritic cells, potentiates T cell survival and increases cytokine production. OX40 has been shown to activate NF-κB-mediated memory cell generation through its interaction with adaptor proteins TRAF2 and TRAF5. OX40 has a critical role in the maintenance of an immune response beyond the first few days and onwards to a memory response. | |
| II. Description | |
Recombinant CHO stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327). | |
| III. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | OX-40 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | TNFRSF4, ACT35, IMD16, TXGP1L, Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4, CD134 |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12k+10%FBS+5ug/ml puromycin |
| Application(s): | Binding Assay,FACS |
| Storage: | Liquid nitrogen |
| IV. Description of Host Cell Line | |
| Organism: | Cricetulus griseus, hamster, Chinese |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
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Figure 1. Recombinant CHO stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327). | |
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