| CBP73231 | |
| I. Introduction | |
Cell Line Name： | KIF5B(E15)-RET(E12) [G810R]/BaF3 |
Host Cell: | BA/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
Mycoplasma Status: | Negative |
| II.Background | |
KIF5B, kinesin family member 5B, is a microtubule motor protein involved in cargo transportation (PMID: 12743033), including lysosome and mitochondria transportation (PMID: 30058692). KIF5B fusions with RET (PMID: 22327624, PMID: 32094155), MET (PMID: 29284707), and ALK (PMID: 21656749, PMID: 21757253) have been frequently identified in lung cancer (PMID: 22327623), and Kif5b expression has been associated with poor prognosis in oral squamous cell carcinoma (PMID: 30058692). | |
| III. Representative Data | |
1. WB of KIF5B-RET (G810R)/BaF3
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2.Sanger of KIF5B-RET (G810R)/BaF3
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3. Anti-proliferation assay | |
Figure 4. CTG Proliferation Assay of BaF3 KIF5B-Ret (S) G810R (C3). | |
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