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[供應(yīng)]315-05-Recombinant Murine IFN-γ
Immune Interferon, type II interferon, T cell interferon, MAF
Catalog Number:
315-05
Synonyms:
Immune Interferon, type II interferon, T cell interferon, MAF
IFN-γ是由CD4和CD8 T淋巴細胞，以及活化NK細胞產(chǎn)生的酸不穩(wěn)定干擾素。的IFN-γ受體存在于大多數(shù)免疫細胞，其響應(yīng)通過增加I類MHC蛋白的表面表達，以IFN-γ信號傳導(dǎo)。這促進了抗原與T-輔助（CD4+）細胞的呈現(xiàn)。的IFN-γ的抗原呈遞細胞和抗原識別B和T淋巴細胞的信令，調(diào)節(jié)免疫應(yīng)答的抗原特異性相。此外，IFN-γ刺激了許多淋巴樣細胞的功能，包括巨噬細胞，NK細胞和嗜中性粒細胞的抗微生物和抗腫瘤應(yīng)答。人IFN-γ是物種特異性的，具有生物活性僅在人類和靈長類動物細胞。重組鼠IFN-γ是含有134個氨基酸殘基15.6 kDa的蛋白質(zhì)。
Description:
IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes, as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting, cells and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant Murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.
AA Sequence:
MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLRLFEVL KDNQAISNNI SVIESHLITT FFSNSKAKKD AFMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Cross Reactivity:
Rabbit, Rat, Mouse, Mouse + Chicken, Human, Cow, N/A, Mouse + Parasite
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