Solution calorimetry measures the heat of solution of a solid dissolving into a solvent. Hogan & Buckton (2000) have shown there is a measurable difference in the enthalpies of solution between the amorphous and crystalline form of a material. Typically, the dissolution of a crystalline material is an endothermic process and exothermic for an amorphous material. Such an ability to differentiate between the amorphous and crystalline form of a material is important to formulators of solid dosage forms for drug delivery.
In all of these forms the assessment of the order or possible disorder associated with the solid material is vital for stability and compatibility testing. Generally the presence of amorphous material influences the physical integrity and usually the kinetics of degradation. Often, only a small amount of amorphous material can produce severe effects on the stability of a particular formulation.
提供商 |
TA儀器 | 下載次數(shù) |
189次 |
資料大小 |
2MB | 資料類型 |
PDF 文件 |
資料圖片 |
點(diǎn)擊查看 | 瀏覽次數(shù) |
454次 |
(空格分隔,最多3個,單個標(biāo)簽最多10個字符)
22
立即詢價
您提交后，專屬客服將第一時間為您服務(wù)