biorelevant FaSSCoF_上海起發(fā)現貨

• FaSSCoF is a biorelevant dissolution medium simulating human fasted state colonic fluid

• Assess how modified release drug products intended for colonic delivery dissolve in fluids in the fasted colon

FaSSCoF

FaSSCoF是一種模擬人類禁食狀態(tài)結腸液的生物相關溶解介質

評估結腸給藥的改性釋放藥物如何溶解在禁食結腸的液體中

Product Description

FaSSCoF is a biorelevant dissolution medium that simulates human fasted state colonic fluid. It contains the appropriate physiological components (bile salt and lipids) reflecting those present in colonic fluids before a meal. This makes FaSSCoF more predictive of solubility and dissolution than plain buffers.

It is used to assess how drugs and modified release drug products intended for colonic delivery dissolve in fasted state colonic fluids. In general, it is less useful for immediate release drugs because absorption of most immediate release drugs are largely complete when the colon is reached and the zone for absorption after oral administration is much smaller than the upper gastrointestinal tract. Here are the specific benefits of using this product:

*Ideal for use in USP dissolution apparatus (if using USP dissolution 1 or USP dissolution 2 apparatus we recommend 900ml of FaSSCoF per vessel)

*Drug analysis can be carried out by HPLC

*Simple and quick preparation method

*Get customized instructions explaining how to make different FaSSCoF volumes from our ‘Media Preparation Tool’ (see above)

產品描述

FaSSCoF是一種模擬人類禁食狀態(tài)結腸液的生物相關溶解介質。它含有適當的生理成分（膽鹽和脂質），反映了餐前結腸液中存在的成分。這使得FaSSCoF比普通緩沖液更能預測溶解度和溶解性。

它用于評估用于結腸遞送的藥物和改性釋放藥物產品如何溶解在禁食狀態(tài)的結腸液中。一般來說，它對立即釋放藥物用處不大，因為當到達結腸時，大多數立即釋放藥物的基本上吸收，并且口服給藥后的吸收區(qū)比上消化道小得多。以下是使用此產品的具體好處：

*非常適合在USP溶出裝置中使用（如果使用USP溶出1或USP溶出2裝置，我們建議每個容器900ml FaSSCoF）

*藥物分析可以通過HPLC進行

*簡單快速的制備方法

*從我們的“Media Preparation Tool"中獲取解釋如何制作不同FaSSCoF卷的定制說明（見上文）