目录:北京索莱宝科技有限公司>>抗体>>Monoclonal Antibody>> K200026MAnti-PARP Monoclonal Antibody
| 供货周期 | 现货 | 规格 | 50ul/100ul |
|---|---|---|---|
| 货号 | K200026M | 应用领域 | 医疗卫生,环保,化工,生物产业,农林牧渔 |
| 主要用途 | WB IHC |
Anti-PARP Monoclonal Antibody
| 英文名称 | Anti-PARP Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 别名 | PARP-1; Poly(ADP ribose) polymerase 1; sPARP1;ADPRT1; ADP ribosyltransferase NAD(+) |
| 应用 | WB IHC |
| 稀释比例 | WB 1:1000-3000. IHC 1:200-500. |
| 交叉反应 | Human |
| 蛋白分子量 | 116kDa |
| Gene ID | 142 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG1 |
| 免疫原 | A synthetic peptide coupled to KLH |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide coupled to KLH |
| Subcellular Locations | Nucleus |
| Swiss Prot | P09874 |
| 克隆号 | M3 |
| 克隆类型 | Monoclonal Antibody |
| 背景资料 | Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. |
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