Levonorgestrel797-63-7

Hexestrol
分子式：C18H22O2   分子量：270.37
 
產(chǎn)品描述
Hexestrol 與ERα和ERβ結(jié)合，EC50分別為0.07 nM 和 0.175 nM。
靶點(diǎn)
ERα
ERβ
       
IC50
0.07 nM (EC50)
0.175 nM (EC50)
       
體外研究
Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM.Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM.Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM.Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM.Hexestrol inhibits 17HSD5 with IC50 of 30 µM, and inhibits TBER1 with IC50 of 0.8 µM.Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen.
體內(nèi)研究
Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes.
溶解性
DMSO 42 mg/mL，水 <1 mg/mL，乙醇 42 mg/mL
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO
特征
Much higher ERβ binding selectivity than Erα