Asenapine Maleate85650-56-2馬來酸阿森那平

馬來酸阿森那平
分子式：C17H16ClNO.C4H4O4       分子量：401.84
 
 
 
產品描述
Asenapine 是adrenergic receptor (α1, α2A, α2B, α2C) 拮抗劑，Ki為0.25-1.2 nM，也是5-HT receptor拮抗劑，(1A, 1B, 2A, 2B, 2C, 5A, 6, 7) Ki為0.03-4.0 nM。
靶點
 
 
 
     
IC50
 
 
 
     
生物活性
Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder.
Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors. Asenapine behaves as an antagonist at all receptors.
溶解性
DMSO 80 mg/mL，水 <1 mg/mL，乙醇<1 mg/mL
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO