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Bovine and Human Type V Collagen

Product	Composition	Quantity	Catalog #
Immunization Grade Bovine Amnion Type V Collagen	[alpha1（V）]₂ alpha2（V）	1 mg, lyophilized	1092
Immunization Grade Human Amnion Type V Collagen	[alpha1（V）]₂ alpha2（V）	1 mg, lyophilized	1095
Immunization Grade Human Placenta Type V Collagen	alpha1（V） alpha2（V） alpha3（V） + [alpha1（V）]₂ alpha2（V）	1 mg, lyophilized	10951

Organ Allograft Rejection
Type V collagen may play a role in graft rejection following lung transplants （See Review: Sumpter TL, Wilkes DS. Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection. Am J Physiol Lung Cell Mol Physiol 2004; 286: L1129-39）. It has been shown that oral tolerance induction by oral administration of type V collagen prevents lung allograft rejection in animal models, and is expected to be used for humans. Importantly, it has been reported that patients who were previously sensitized by type V collagen and positive for type V collagen-DTH reactions tend to develop idiopathic pulmonary fibrosis （58.8%, 10/17） compared to patients who were negative for the DTH reaction （15.8%, 6/38）（Bobadilla JL, Love RB, Jankowska-Gan E, Xu Q, et al. Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation. Am J Respir Crit Care Med 2008; 177: 660-8）.

Type V and Type XI Collagen
Type V collagen is one of the minor collagen components forming interstitial collagen fibrils with type I collagen, and plays a critical role in the regulation of fibrillogenesis. Type V collagen from most tissues consists of two α1（V） and one α2（V） chains, [α1（V）]2α2（V）, whereas the placenta contains two subtypes of type V collagen, [α1（V）]2α2（V） and α1（V）α2（V）α3（V）. Type V collagen is closely related to type XI collagen consisting of three different alpha chains, α1（XI）, α2（XI）, and α3（XI）, which co-exists with type II collagen in articular cartilage, and regulates fibrillogenesis of type II collagen. Since type V and type XI collagen share nearly 80% homology, type XI collagen may be a suitable reference for assaying antibodies to type V collagen.

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