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IL-12 is a heterodimeric pleiotropic cytokine made up of a 40 kDa （p40） subunit and a 35 kDa （p35） subunit.IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma （IFN-γ） and tumor necrosis factor-alpha （TNF-α） from T cells and natural killer （NK） cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer （NK） cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.