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IL-28A, IL-28B, and IL-29, also named interferon-lambda 2 （IFN-lambda 2）, IFN-lambda 3, and IFN-lambda 1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family （11-13% a.a. sequence identity） and the type IIFN family （15-19 % a.a. sequence identity）. The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and upregulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor lambda （IL-10 R beta） and a novel IL-28 receptor alpha （IL-28 R alpha, also known as IFN-lambda R1）. Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation.